Ac3-6AzGlcNAc,代谢标记物
作者：乐虎lehu唯一官网 发布时间：2022-07-14 14:44:05
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Ac3-6AzGlcNAc,代谢标记物
6-azido-6-deoxy-N-acetyl-glucosamine triacylated (Ac3-6AzGlcNAc)
6-azido-6-deoxy-N-acetyl-glucosamine triacylated (Ac36AzGlcNAc) is an azide-containing, specific metabolic chemical reporter for O-GlcNAcylated proteins. Notably, 6AzGlcNAc cannot be biosesynthetically transformed into the corresponding UDP sugar-donor by the canonical salvage-pathway that requires phosphorylation at the 6-hydroxyl. In vitro experiments showed that 6AzGlcNAc can bypass this roadblock through direct phosphorylation of its 1-hydroxyl by the enzyme phosphoacetylglucosamine mutase (AGM1). The azide-modified protein is detected with either fluorescent alkynes or biotin alkyne. The acetyl groups increase cell permeability and allow the unnatural sugars to easily pass through the cell membrane. Carboxyesterases remove the acetyl groups once the monosaccharide is in the cell.
Molecular weight
372.33
Chemical composition
C14H20N4O8
CAS
N/A
Solubility
DMSO, DMF, DCM, THF, Chloroform
Purity
>90%
Appearance
White to grey amorphous solid
Storage conditions
-20C
Shipping conditions
Ambient temperature
Ac3-6AzGlcNAc,代谢标记物
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